Upcoming Virtual and In-Person Educational Events for Patients and Medical Professionals ➜ VIEW NOW

Introduction to the Byron White Formulas And Their Use in Lyme Disease

Introduction to the Byron White Formulas And Their Use in Lyme Disease

Please understand that Dr. Anderson and Gordon Medical cannot prescribe or recommend treatment to patients they have not seen. Byron White Formulas are only available to current GMA patients by prescription.

The formulas have changed since these articles were written, and suggested dosages are now different. Contact your practitioner to adjust your treatment. This information is provided for educational purposes only, and is not intended to diagnose or treat an individual.

The Missing Piece in Lyme Disease Case Management

By Wayne Anderson, ND

Having practiced medicine for 30 years, I know how hard it can be to take on new therapeutic tools. As busy practitioners, we are inundated with the latest and greatest. But I believe when you begin using the Byron White Formulas, you’ll quickly appreciate their distinct benefits.

Wayne’s Bio

My background has been 30 years of experience in family medicine in Lyme-endemic Northern California. I worked with four, family practice doctors, all who were confused by the high incidence of Chronic-Fatigue-Illnesses in our rural community. I took on the challenge of these sick patients using my Naturopathic background along with allopathic protocols. I tried to help these CFIDS patients by focusing on mold and Candida, heavy metals, and viral protocols, and saw only marginal improvement. I became well versed in Functional Medicine, balancing the gut, hormones, immune system and nervous system, yet again without unlocking the symptom pattern that plagued these patients.

Dr. Burrascano to the Rescue!

In the early 90’s, I was introduced to Joe Burrascano and for the first time I began to consider that a tick-borne infection could be the epidemiologic factor in these chronically disabled patients. As my “index of suspicion” rose so did the number of cases that responded to antibiotic treatments.

“There is No Lyme disease in California” – Wrong!

I realized one patient at a time that the neurological symptoms I was unsuccessful at treating were related to Lyme disease. It was difficult to take this stand at the time as the entire medical community, from the excellent family practice practitioners to a UCSF Neurologist and Infectious Disease (ID) specialist, absolutely excluded Lyme as a possibility. We have come a long way in the last 20 years to realizing that Lyme disease can be the underlining reason for scores of diagnoses. Now we must all include it in our differential diagnosis for any neurologic symptom or chronic-fatigue-like-illness. I now treat patients from all over the country and continue to be amazed as to the prevalence of these infections.

My Learning Curve

In the early 90’s, my experience was that treating these infections with natural, functional medicine protocols were not enough to help most patients. I committed to a decade of full-court-press antibiotic protocols: high dose cell membrane agents with one or more intracellular agents. This did help more patients but I still was not satisfied.

With a greater understand of the true nature of these infections and exciting research has brought us to renewed approaches to treatment. With this knowledge I went back to the new and exciting herbal, nutraceuticals, and Homeopathic protocols. I found that many of the new tools we had were helpful. But it was not until I was introduced to the Byron White Formulas (BWFs) did I find the “missing piece” in Lyme disease treatment. Not only have they helped thousands of my patients over the last ten years (as specific provoking agents), but they have clarified the nature of how these bacteria behave through their supportive qualities.

The Evolution of My Interest in These Disorders

The unprecedented prevalence motivated me to specialize in treating these disorders. I have researched these infections with experts from all over the world. My relationship with Byron White has been indispensable in understanding how to effectively treat these patients. I have become increasingly motivated to teach and spread awareness regarding the nature of these illnesses. I have presented at major conferences including the International Lyme and Associated Diseases Society (ILADS), the American College for Advancement in Medicine (ACAM),  Orthomolecular Health Medicine (OHM), and Lyme Induced Autism (LIA),

Why Lyme Disease Has Polarized the Infectious Disease Community

Changing Our View of Lyme Disease from Infectious Disease to Functional Illness
Our understanding of this enigmatic family of infections has logarithmically increased over the past 20 years due to 5 key factors:

Factor #1: We appreciate the nature of their pathogenicity related more to the compromise of cell function, over the standard infectious disease model of microbes that destroy cell structure. As these microbes build up in the cells, function is compromised. The greater the load, the more severe the symptoms.

Factor #2: This makes each patient’s symptomatic presentation different depending on their strengths and weaknesses. This confuses the Infectious Disease (ID) community that expects patients’ symptoms to be consistent with the pathogen they are exposed to.

Factor #3: The ID community relies on lab tests (bacterial culture and sensitives) to guide treatment. Yet few lab tests exist at this time that can help us navigate through the treatment of the family of tickborne infections.

Factor #4: Having success at treating acute cases of Borrelia burgdorferi in the late 70’s, the CDC viewed the infection as only having an acute presentation. And as these patients with the spirochete responded to 30 days of antibiotics it was thought to be like syphilis, easy to treat with a short course of antibiotics.

Factor #5: The CDC has not updated their antiquated view on Lyme disease despite the knowledge we have amassed from more than 20 years of clinical work and research.

Common Diseases That Can Mimic or Be Triggered by Lyme Disease
  • Multiple Sclerosis (MS)
  • Amyotrophic lateral sclerosis (ALS)
  • Parkinson’s disease
  • Rheumatoid Arthritis (RA)
  • Lupus
  • Reflex Sympathetic Dystrophy (RSD)
  • Polymyalgia Rheumatica
  • Chemical Sensitivity
  • Bipolar Disorder
  • Autism
  • Fungal Hypersensitivities
  • Autoimmune Disorders
  • Hashimoto’s Thyroiditis
  • Graves disease
  • Hypothyroid
  • Adrenal insufficiency
  • Hyperparathyroidism
  • Addison’s disease
  • Menopause – other hormone transitions
  • Any mental health presentation
  • Schizophrenia
We Are Really Treating the Broader Family of Neurotoxins
After treating thousands of Lyme patients over the last 20 years, I have come to the following conclusions

It’s not just about Lyme disease. It is a family of pathogens including Borrelia (BbLO), Babesia Like Organisms (BabLO), Bartonella Like Organisms (BLO), Ehrlichia, Anaplasma, Mycoplasma, fungal toxins, heavy metals, and chemical toxins.

Neurotoxins Share Common Mechanisms of Action
  • These pathogens are lipophilic.
  • They result in an inflammatory response.
  • They build slowly within the cell.
  • They have an additive effect.
  • They disrupt the bodies self-regulatory systems (endocrine, nervous, immune, and GI systems).
  • The severity of the patient’s symptoms relates to pathogen load.
  • The greater the stored load, the worse the patient’s symptoms.
The 3 Aspects and 8 Key Principles of Chronic Lyme Disease Treatment

All aspects of treatment can be related to one of the following categories:

  1. Immune Modulation
  2. Kill or unloading the dominant pathogen
  3. Waste Removal / Terrain Rejuvenation

After diagnosis has been confirmed, and the patient has begun to respond to treatment, we must also rebuild metabolism and repair physiology.

As we better understand the nature of Lyme disease, we will be more effective with our treatment.

Principle #1
There is wisdom in the body’s symptom presentation
  • The immune system is prioritizing what it perceives as its greatest threat.
  • Symptoms are not due to the pathogen itself, but to the immune system’s recognition of the pathogen as a threat.
  • The more exaggerated the symptom pattern, the more difficulty the immune system is having at controlling this invader.
  • Symptom presentation will be shaded by the integrity of each individual’s multiple homeostatic mechanisms.

BWFs application: They function as specific immune provoking agents that can support the immune system to reduce the load.

Principle #2
Another of the complexities in treating these infections is their organism diversity
  • Borrelia (40 species in N. America and 300 worldwide)
  • Babesia (> 100 species)
  • Bartonella/Bartonella Like Organisms (26 species)
  • Ehrlichia/Anaplasma
  • Mycoplasma (9 vs. >100 Species)

BWFs application: These complex herbal formulas have an extensive historic application as general antimicrobials, as opposed to targeting one specific mechanism. This gives then broad application even for microbes that we have yet to uncover.

Principle #3
What the immune system cannot resolve it stores

If the immune system cannot resolve and clear a neurotoxin it will store it. Over the years this results in layers that takes energy to maintain. This “gunk” can be deposited in the vascular system, against the artery walls, in the capillary beds, stuck in fat, and in the intracellular and extracellular space. The bowel, liver, adipose tissue and lymphatic system can be a storage repository for these toxins.

BWFs application: Supports the body’s detox systems.

Principle #4
It’s all about “Who’s on top?

The immune system is always prioritizing what it perceives as its dominant threat. This will change dynamically depending on the body’s stressors. If you think you are just treating Borrelia, you are not looking deep enough. With tick borne exposure, it is very likely we are dealing with “all the bugs all the time”! It’s not just Borrelia, but this complex family of microbes, with the Babesia Like Organisms (BabLO) and Bartonella Like Organisms (BLO) being the dominant pathogens. And it is all about “who’s on top?”

BWFs application: My Challenge protocol is the best way to understand what pathogen is the most dominant.

Principle #5
Individual symptom variability

What is confusing to the conventional ID community is that no two patients with Lyme disease show the exact same symptoms. Because these microbes are affecting function over structure, each patient’ strengths and weaknesses will change their symptomatic presentation.

BWFs application: The formulas work on multiple organ systems to support each individual in a way to better cope with their specific infection.

Principle #6
Pattern recognition, or connecting the dots

Recognizing the patterns that can be related to Babesia-Like-Organisms (BabLO), Bartonella-Like-Organisms (BLO), or Borrelia burgdorferi-Like-Organisms ( BbLO) required a different way of thinking than our conventional medical training. We were taught to focus on one-organ system and exclude symptoms from other organ systems that don’t fit in. This thinking is very efficient in ruling out conditions such as Myocardial Infarction (heart attack)  or pneumonia.

But for functional infections this exclusion process will not work. Chronic Lyme disease diagnosis and treatment needs to be inclusive. It is much like a complex “connecting the dots” puzzle. In this puzzle, you have what look for random data points without any apparent relationship. When, one-by-one, you begin to “connect the dots,” the picture emerges. We are looking for the relationship of what at first may seem like unrelated data points, but eventually emerge as a coherent picture.

BWFs application: Supports the immune system to more specifically clarify what it is struggling with.

Bartonella-Like-Organisms Subset

Keynote: Bottoms of feet painful, burning, and/or numb. Pain; joint specific pain, pain in general. Lymphadenopathy. Gastritis. Conjunctivitis. Mildly elevated liver enzymes and/or splenomegaly. Headache. Feeling hot to occasional fever.
Mood: Moderate to severe
Cognitive: moderate to severe
Pain: Severe
Sleep: Significant disruption

Babesia Species Subset

Keynote: Severe depression (suicidal ideation) and/or severe agitation. Drenching sweats with chill and/or hot, temperature intolerance. shortness of breath (SOB). Tachycardia.
Mood: Severe
Cognitive: Severe
Pain: Seldom (occasional ankles/feet, wrists/hands.)
Sleep: Disruptive sleep, frequent waking

Borrelia Dominant Subset

Keynotes: Dominant when rare, aggressive organisms are present, or with repeated exposures over the years. Usually underlying other more dominate pathogens, and treated later. Slowest growing and most neurologically generalized. Prioritize when CD57 is below 30 with HLA 15-3-51 and /or 16-6-53.
Mood: Moderate
Cognitive: Moderate
Pain: Moderate to severe, generalized achy, unilateral and wandering
Sleep: Mildly disruptive

Principle #7
Healing is unwrapping this package

We need to systematically unravel the layers that have been stored to protect the system from the potential damage the pathogens can cause. Symptomatic improvement can be related to peeling away the layers, systematically unloading the pathogens from within the cells.

BWFs application: Supportive to help the body release and clear stored layers.

Principle #8
The patient’s response to a challenge with an isolated variable is the only way the practitioner can confirm the patient’s diagnosis

Three Steps for Making the Diagnosis

  • Create a hypothesis regarding the presumed dominant pathogen (after taking a detailed history, doing a physical exam, and evaluating relevant lab work).
  • Challenge the patient with a therapeutic intervention that is as specific as possible to the suspected pathogen.
  • The patient’s response to this variable is as good as we get for confirming the diagnosis.
Review of Definition of Terms

Dr. Burrascano’s Definitions for Lyme

  1. Lyme disease (interchangeable with Lyme): “This infection includes not only Borrelia burgdorferi but the many co-infections that may result.”
  2. Chronic Lyme disease: “In the chronic form of Lyme, other factors can take on an ever more significant role; immune dysfunction, opportunistic infections, co-infections, biological terrain, metabolic and hormonal imbalances, deconditioning, etc.”
  3. Lyme Borreliosis: “Solo infection with B. burgdorferi.”

Neurotoxin Illness: Inflammation related to tick borne illness, fungal or chemical toxin.

Functional Medicine: Focus on improving physiologic function as the primary way of improving the health of patients with chronic illness.

Provoking agent: Prescription, herbal or homeopathic that can augment the immune system to have a beneficial effect. This could result in an aggravated response (Herx reaction) or improve the patient’s symptom picture.

Symptom Picture: Symptoms from various organ systems that when viewed as a whole can reflect the immune systems reaction to a specific pathogen.

Load: Pathogenicity of neurotoxin illness is related to the additive effect of lipophilic substances.

Clear Pattern: Vital immune response in a healthy patient that recognizes an aggressive co-infection. The resulting symptoms are related to the recognition and response of the immune system to that pathogen as a perceived threat.

Muddy Pattern: Immune response that is less well organized in its defense against a co-infection. This patient can have co-morbidities that result in a less defined response. This patient usually has chemical or metal toxins that are compromising the system.

Mixed Pattern: This patient also can have equally aggressive pathogens (usually Babesia and Bartonella) that result in elements of each in a changeable dynamic pattern.

Treatment of Chronic Lyme Disease is Like Playing Chess

There is An Opening (making the diagnosis) A Middle Game (timing your move in relation to the changing pathogen picture relative to the patients strengths and weaknesses). And An End Game (immune rehab, terrain rebuilding, final unloading, etc).

Index of Suspicion/ Expanding our Differential Diagnosis

Chronic Lyme disease needs to be included in the differential diagnosis of any neurological or psychiatric presentation. Our Index of Suspicion needs to increase. We are missing many patients who show these neurological symptoms and often are not responding to treatment protocols as expected.

Making the Diagnosis

First we need a need to have a higher index of suspicion for the prevalence of tick-borne pathogens. Much has been said about Lyme disease being a hidden epidemic. Where we got off track was thinking that Lyme disease was just about Borrelia. When considering the Borrelia seropositive patient or the patient with a symptom picture that is suspect of Borrelia, we must consider the very likely probability of one or more coinfections. A positive lab test for a co-infection can be reassuring, and is present about 30% of the time. 70% of patients with a negative test respond and improve symptomatically when treated with protocols that work against BabLO or BLO. So it all comes down to becoming better at Pattern Recognition (Clear, Muddy, Mixed).

Benefits of the BWF in Lyme Disease Case Management
  • These formulas are powerful immune system provoking agents; a one-drop increase can evoke a response.
  • In my experience this response is the best indication of the dominant pathogen.
  • The formulas have flexible dosing. Unlike antibiotics they remain effective at any dose. Patients will respond individually in relation to pathogen load, and their overall strengths and weaknesses.
  • There is no risk of developing organism resistance.
  • A Herx response can develop from exceeding the correct dosage for the individual patient.
  • This aggravated response will subside as the dose is decreased.
  • When the dose is decreased there is a one to three day wash out period before the patient will get back to their pre-Herx baseline.
  • The historical uses of the herbs in these formulas indicate that they will focus on a primary pathogen and also have multiple secondary pathogen responses.
  • The BWFs enhance the immune suppressed patient. In my experience the clinical picture clarifies with their use making it easier for the practitioner to decide when to adjust treatment.
  • These formulas are safe without toxicity.
  • And unlike antibiotics they are virtually side effect free. If there is a response it will be immune, endocrine, neurological and energetically supportive to the healing process.
This Is the True Art of Medicine
  • Listen to your patient.
  • Do the best you can to do right thing at the right time.
  • Take whatever comes from that and use it in the next step.
Wayne Anderson, ND
Wayne Anderson, N.D.
Naturopathic Doctor/Independent Practitioner
“Patient care must integrate mind and body, incorporating the strengths of alternative and conventional medicine, and tailoring a program that recognizes the uniqueness of each person.” For more than 25 years, Dr. Anderson has known that his patients are partners in the process of learning about and treating their illness, whether they choose conventional or alternative medicine or a combination of both. He listens to understand each patient’s strengths and challenges and improve his effective interaction with them. He sees every person as complex, integrated, and unique, and believes that treatment should optimize health and well-being.
Lyme Disease Treatment at GMA

Copyright 2016 Wayne Anderson
All rights reserved.
For information or permission contact Wayne Anderson, N.D.

More Articles