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Lyme Disease Treatment with Wayne Anderson, ND

Walking into the Mist - Photo by Maulana on Unsplash

Wayne Anderson has a practice with a concentration on chronic illness, using tools and experience from both conventional and integrative medicine. At Gordon Medical Associates, as an Independent Practitioner with a growing focus on Lyme disease, he developed a deeper understanding of chronic illness, its treatment, and the frontiers still available as possible solutions.

Since becoming aware of this (Lyme disease) in the early 90’s he implemented protocols using natural, functional medicine and antibiotic agents. This approach helped, but he was still not satisfied with the results. He researched Lyme and gained a much greater understanding of the true nature of the infection. Exciting research has brought tremendous improvements to the approaches for treatment. Armed with this new knowledge he again began using herbal, nutraceutical and Homeopathic protocols. Then he was introduced to the Byron White Formulas (BWFs) which he now believes to be the missing piece in Lyme disease treatment.

Dr. Anderson has researched these infections with experts worldwide. With the input of Byron White, he has developed protocols that are extremely effective in patient therapy. Over the last six years the Byron White Formulas have helped thousands of his patients and have also clarified the nature of how Lyme and co-infection bacteria behave.

A curious and dedicated clinician, Dr. Anderson is committed to the ongoing process of learning and teaching. In addition to his clinical practice, Dr. Anderson maintained his initial focus on teaching. For over 20 years he taught medical students at Touro Osteopathic Medical School, and supervised residents from Sutter Hospital and interns from the Physician Assistant programs in the clinic setting. He is also a popular speaker on the topics of Lyme disease and neurotoxin illness. He has spoken at conferences for the International Lyme and Associated Diseases Society (ILADS), the American College for Advancement in Medicine (ACAM),  Orthomolecular Health Medicine (OHM), and Lyme Induced Autism (LIA), as well as select private symposiums on CFIDS, Lyme, and Autism.

For more than 25 years, Dr. Anderson has known that his patients are partners in the process of learning about and treating their illness, whether they choose conventional or alternative medicine or a combination of both. He listens to understand each patient’s strengths and challenges and improve his effective interaction with them. He sees every person as complex, integrated, and unique, and believes that treatment should optimize health and well-being.

See Dr. Anderson's full bio

It's More Than Just Lyme Disease

We originally thought of Lyme disease as primarily an infection caused by the spirochete Borrelia burgdorferi. In the decades that followed, researchers began identifying other tick-borne bacteria and toxins that frequently accompany Lyme infections. We have come to realize that the symptoms which we once described as “Lyme disease” frequently involve other bacteria, such as Babesia, Bartonella, Ehrlichia, or Mycoplasma, or rarer species such as the Rickettsia group or tularemia. Transmitted in the digestive tract of ticks or fleas, these pathogens may be carried by cats, rats, mice, deer, and other animals, depending on the microbe. These pathogenic bacteria are among the smallest known life-forms on earth. Unlike most bacteria, they are harbored within the cell as a virus would be or within the interstices between the cells, making it difficult for the immune system to dislodge them. Fungal toxins, heavy metals and chemical toxins may also be part of the picture. All of these being neurotoxic in nature. There are common mechanisms of action with all of these which can result in inflammation, build up in the cell and disrupt self-regulatory mechanisms.

Under this protocol, Lyme disease is viewed more as a functional illness than an infectious disease. There are several key factors that relate to this shift in thinking. One is the view that the nature of Lyme’s pathology was related more to the compromise of cell function that arises. The greater the load in the cell, the more severe the symptoms. As a result, the symptoms vary from person to person depending on their individual strengths and weaknesses, creating inconsistencies in presentation. A third factor is that lab tests for Lyme aren’t precise enough to help navigate through the various elements of tick-borne infections. And finally, as a result of antiquated policy, the CDC has not updated their view of Lyme disease.

Neurotoxic Disorders: Reactivity to Lyme, Coinfections, Molds, And Petrochemicals

How the Lyme Bacteria Evades the Immune System

What we (now) know about the organism [borrelia] is that it goes through different phases – the spirochetal phase, a cell-wall-deficient phase, and a cystic phase. It has genetic complexities that allow it to adapt to different environments, different stresses; it can go dormant, it can take advantage of the patient’s weakness, it can hide in poorly circulated areas.

With this in mind, Dr. Anderson finds that his treatment has three aspects. First is immune modulation, second is killing and unloading the dominant pathogen, and finally, removing the waste and rejuvenating the terrain of the body.

Lyme Complex: Taxonomy and Treatment

There are Three Steps for Making the Diagnosis of Lyme Disease


Create a hypothesis regarding the presumed dominant pathogen (after taking a detailed history, doing a physical exam, and evaluating relevant lab work). First we need to have a higher index of suspicion for the prevalence of tick-borne pathogens. Much has been said about Lyme disease being a hidden epidemic. Where we got off track was thinking that Lyme disease was just about Borrelia.


When considering the Borrelia seropositive patient or the patient with a symptom picture that is suspect of Borrelia, we must consider the very likely probability of one or more co-infections.


A positive lab test for a co-infection can be reassuring, and is present about 30% of the time. 70% of patients with a negative test respond and improve symptomatically when treated with protocols that work against Babesia Like Organisms (BabLO) or Bartonella Like Organisms (BLO). These are infectious organisms for which we may not yet have a test, but which can respond to treatment.

Mold and Lyme Disease

Anderson has found that if one was born with a predisposition to mold biotoxins activated early on in life and later was infected with Lyme and associated coinfections, Lyme disease may be layered on top of the underlying fungal issue, and the fungal issue may not be what the person needs to address at that time. If the Lyme-related infections are what is drawing the attention of the immune system at that moment, it may only be after this layer is addressed that the fungal symptoms appear. In other words, some patients can have a significant mold load, but the practitioner may not be able to address that issue until the body is no longer being provoked by the Lyme layer.

Mold and Mycotoxins: Often Overlooked Factors in Chronic Lyme Disease

Seasonal Changes in Symptoms and Treatment Needs

Anderson has also observed that there can be seasonal influences that affect the primary (infectious) layer that the body is dealing with. The immune system may have prioritized Lyme or a particular coinfection and may be ignoring underlying fungal issues; this can then flip in the winter when the rain hits. The increased exposure to molds in the winter may lead to the reprioritization of the fungal layer by the immune system. At that point, Anderson may need to shift from treating the Lyme-related issues to treating the mold issue. If mold allergy is present, this may also be seasonally influenced. The protocols are dynamic and must constantly be adjusted based on several factors such as the environment, new exposures, and what the immune system deems the dominant issue or pathogen.

Mold and Mycotoxins: Often Overlooked Factors in Chronic Lyme Disease

Autoimmune Reactions

The toxins (from Lyme and coinfections) trigger an inflammatory response, stimulating the release of both anti-inflammatory and pro-inflammatory cytokines, generated by the immune system in its attempts to restore balance and reduce inflammation. As the system becomes upregulated, that typically causes a greater predominance of pro-inflammatory cytokines and autoimmune symptoms. This is the immune system spinning out of control – what would normally be a protective process becomes unproductive as the system becomes overwhelmed.

Neurotoxic Disorders: Reactivity to Lyme, Coinfections, Molds, And Petrochemicals
Lyme Disease as a Functional Illness

Our goal as practitioners is to accumulate as much information as possible regarding the health of the individual patient who sits in front of us. Identification of symptom patterns associated with the presence of specific pathogens can be useful in developing a hypothesis. These patterns are also helpful in testing that hypothesis with a challenge protocol.

Every patient will be a little different in relation to how he or she manifests symptoms. Each patient’s symptoms will reflect that individual’s genetic vulnerabilities and health history.

There are common diseases that can mimic Lyme disease and also be triggered by Lyme. Some of these include Multiple Sclerosis, Parkinson’s, Rheumatoid Arthritis, Lupus, CIFDS, Chemical Sensitivity, Bipolar, ADHD, ADD, Autism, Fungal Hypersensitivities, Hashimoto’s Thyroiditis, Graves Disease, Hypothyroid, Adrenal insufficiency, Addison’s disease, mental issue and hormone transition issues, to mention a few.

Mold and Mycotoxins: Often Overlooked Factors in Chronic Lyme Disease

In his own practice, Dr. Anderson uses the following process to develop and assess patients.

4. Finding the Dominant Infection

It is highly likely that a patient is infected with not only the Borrelia but with one or more of the co-infections also known as tick-borne diseases. The symptoms presenting will be an indication of what the immune system perceives as the dominant threat. By using Dr. Anderson’s “Challenge” protocol with the Byron White Formulas (BWFs) it is possible to determine the pathogen that is dominant at the moment.

Introduction to the Byron White Formulas and their use in Lyme disease
6. Coinfections

Lyme and its co-infections Babesia Like Organism (BabLO), Bartonellla Like Organsim (BLO) or Borrelia Like Orgaism (BbLO) all have different patterns. The practitioner needs to learn to connect the dots until the patient picture develops to determine correct treatment in the moment. BWFs support the immune system so it is easier to connect these dots and see the whole picture.

A Deep Look At The Symptoms Of Six Major Lyme-Related Infections