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The Cell Danger Response and Chronic Illness

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Dr. Jill Interviews Dr. Eric Gordon on The Cell Danger Response in Chronic Lyme disease. 

Highlights

  • The Cell Danger Response (CDR) is defined in terms of an ancient metabolic response to threat.
  • The CDR encompasses inflammation, innate immunity, oxidative stress, and the ER stress response.
  • The CDR is maintained by extracellular nucleotide (purinergic) signaling.
  • Abnormal persistence of the CDR lies at the heart of many chronic diseases
  • Antipurinergic therapy (APT) has proven effective in many chronic disorders in animal models.

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